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LOMBARDI Angela, University of Napoli Federico II, Italy

Peptides and metal ions: a successful marriage for developing artificial metalloenzymes


Angela Lombardi is Professor of Inorganic and Bioinorganic Chemistry at the University of Napoli Federico II (Italy). She received her PhD in Chemical Sciences in 1990. In the same year, she was tenured as research associate at the Department of Chemistry, and then promoted to associate and full professor. She spent numerous sabbatical periods in the United Stated: she was visiting scientist at DuPont Merck Pharmaceutical Company, Wilmington (1995-1996), at the University of Pennsylvania (1997), and at the University of California, San Francisco (2013). Her research interest spans the areas of coordination and bioinorganic chemistry, and protein design. Her activity mainly focuses on the structure/function relationships of metalloproteins and metalloenzymes, and it is particularly aimed at reproducing in simpler systems the unique properties of metal ions when coordinated to complex protein ligands. She has significantly contributed to the development of artificial metalloenzymes (containing heme-, diiron-oxo-, iron-sulfur and copper centers) using a minimalist and/or a de novo design strategy. Such approaches have allowed the construction of functional molecules, able to catalyze oxidation, oxygenation and hydrogen evolution reaction, thus useful for application in catalysis, energy production, and in the construction of functional nanomaterials and biosensors.